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Article

Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family

1 Jan 2012

Abstract excerpt

Accumulating evidence suggests that various diseases, including many types of cancer, result from alteration of subcellular protein localization and compartmentalization. Therefore, it is worthwhile to expand our knowledge in subcellular trafficking of proteins, such as epidermal growth factor receptor (EGFR) and ErbB-2 of the receptor tyrosine kinases, which are highly expressed and activated in human...

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PMID: 22520625
DOI: 10.1186/2045-3701-2-13

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