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Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery.

Biochemistry. Biokhimiia - 1 Sept 2020

Rosenkranz A A, Slastnikova T A

Abstract excerpt

Epidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular response to a number of growth factors. Its overexpression and increased activation due to mutations is one of the most common traits of many types of cancer. Development and clinical use of the agents, which block EGFR activation, became a prime example of the personalized targeted medicine. However, despite the obvious...

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PMID: 33050847
DOI: 10.1134/S0006297920090011

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