Article
Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.
The Journal of biological chemistry - 3 Mar 1995
Opresko L K, Chang C P, Will B H, Burke P M, Gill G N, Wiley H S
Abstract excerpt
Ligand-induced internalization of the epidermal growth factor receptor (EGFR) leads to accelerated receptor degradation. Two models have been proposed to explain this. In the first model, induced internalization expands the intracellular pool of receptors, leading to enhanced lysosomal targeting....
Topics
- Animals
- Biological Transport
- Endocytosis
- ErbB Receptors
- Lysosomes
- Mice
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Tyrosine