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Article

Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway.

Biochemical and biophysical research communications - 26 Aug 2011

De Angelis Campos Ana Carolina, Rodrigues Michele Angela, de Andrade Carolina, de Goes Alfredo Miranda, Nathanson Michael H, Gomes Dawidson A

Abstract excerpt

The epidermal growth factor (EGF) transduces its actions via the EGF receptor (EGFR), which can traffic from the plasma membrane to either the cytoplasm or the nucleus. However, the mechanism by which EGFR reaches the nucleus is unclear. To investigate these questions, liver cells were analyzed by immunoblot of cell fractions, confocal immunofluorescence and real time confocal imaging. Cell fractionation studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21821003
DOI: 10.1016/j.bbrc.2011.07.100
PMCID: PMC3572844

Genes

EGFR
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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