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Article

A direct role for Met endocytosis in tumorigenesis.

Nature cell biology - 5 Jun 2011

Joffre Carine, Barrow Rachel, Ménard Ludovic, Calleja Véronique, Hart Ian R, Kermorgant Stéphanie

Abstract excerpt

Compartmentalization of signals generated by receptor tyrosine kinase (RTK) endocytosis has emerged as a major determinant of various cell functions. Here, using tumour-associated Met-activating mutations, we demonstrate a direct link between endocytosis and tumorigenicity. Met mutants exhibit increased endocytosis/recycling activity and decreased levels of degradation, leading to accumulation on endosomes,...

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PMID: 21642981
DOI: 10.1038/ncb2257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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