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Article

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.

The Journal of cell biology - 31 May 2010

Goh Lai Kuan, Huang Fangtian, Kim Woong, Gygi Steven, Sorkin Alexander

Abstract excerpt

Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis mechanisms are poorly understood, which precludes development of approaches to specifically inhibit EGFR endocytosis and analyze its impact on signaling. Using a combination of receptor mutagenesis and RNA interference, we demonstrate that clathrin-dependent internalization of...

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Source

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Identifiers

PMID: 20513767
DOI: 10.1083/jcb.201001008
PMCID: PMC2878939

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.Semantic proximity Read ↗

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