Article
Frequencies of Bcl I, E22E, and N363S of h-GR/NR3C1 restriction fragment length polymorphisms of glucocorticoid receptor gene in Polish adult population.
Medical science monitor : international medical journal of experimental and clinical research - 1 Oct 2010
Pietras Tadeusz, Panek Michal, Kuprys-Lipinska Izabela, Oszajca Katarzyna, Wujcik Radoslaw, Kuna Piotr, Gorski Pawel, Szemraj Janusz
Abstract excerpt
BACKGROUND: Polymorphism of the gene encoding the glucocorticoid receptor - h-GR/NR3C1 demonstrates close genetic and biochemical correlation with etiopathogenesis of metabolic, cardiovascular, hematologic, and mental disorders. The natural variability of DNA sequence within the h-GR gene affects both the conformation and the activity of glucocorticoid receptors. Modifications of the amino acid receptor structure...
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