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Article

Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single gene

8 Feb 2019

Abstract excerpt

BACKGROUND: Glucocorticoids are commonly used in the clinical setting for their potent anti-inflammatory effects; however, significant variations in response to treatment have been demonstrated. Although the underlying mechanisms have yet to be fully understood, this variable response may be a result of alterations in human glucocorticoid receptor (hGR) expression and function. In addition to hGRα, the...

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PMID: 30736733
DOI: 10.1186/s12863-019-0718-z

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