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Article

Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure.

Antiviral research - 1 Dec 2010

Codoñer Francisco M, Pou Christian, Thielen Alexander, García Federico, Delgado Rafael, Dalmau David, Santos José Ramon, Buzón Maria José, Martínez-Picado Javier, Alvarez-Tejado Miguel, Clotet Bonaventura, Ruiz Lidia, Paredes Roger

Abstract excerpt

Using quantitative deep HIV-1 sequencing in a subject who developed virological failure to deep salvage therapy with raltegravir, we found that most Q148R and N155H mutants detected at the time of virological failure originated from pre-existing minority Q148R and N155H variants through independent evolutionary clusters. Double 148R+N155H mutants were also detected in 1.7% of viruses at virological failure in...

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Identifiers

PMID: 20883724
DOI: 10.1016/j.antiviral.2010.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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