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Article

Longitudinal analysis of integrase N155H variants in heavily treated patients failing raltegravir-based regimens.

HIV medicine - 1 Feb 2013

Nguyen H L, Charpentier C, Nguyen N, de Truchis P, Molina J-M, Ruxrungtham K, Delaugerre C

Abstract excerpt

OBJECTIVES: The mechanism of raltegravir (RAL)-resistant evolutions has not already been elucidated. Because the emergence of RAL resistance is usually initiated by the N155H mutant, we assessed the role of minor N155H-mutated variants in circulating RNA and archived DNA in five heavily treated patients experiencing long-term RAL therapy failure and harbouring three different resistance profiles determined by...

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Identifiers

PMID: 22994529
DOI: 10.1111/j.1468-1293.2012.01039.x

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