Article
Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.
PloS one - 1 Jan 2011
Codoñer Francisco M, Pou Christian, Thielen Alexander, García Federico, Delgado Rafael, Dalmau David, Álvarez-Tejado Miguel, Ruiz Lidia, Clotet Bonaventura, Paredes Roger
Abstract excerpt
OBJECTIVE: To explore the potential of deep HIV-1 sequencing for adding clinically relevant information relative to viral population sequencing in heavily pre-treated HIV-1-infected subjects. METHODS: In a proof-of-concept study, deep sequencing was compared to population sequencing in HIV-1-infected individuals with previous triple-class virological failure who also developed virologic failure to deep salvage...
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