Article
Next-generation sequencing reveals major and minority HIV-1 drug resistance mutations in treatment-experienced individuals with virological failure.
Acta tropica - 1 Sept 2026
Duro Rodrigo Lopes Sanz, da Silva Luiz Claudio Santana, Castro Daniela Funayama, Ferreira Maira Cícero, Arnold Rafael, Galinskas Juliana, Martins Junior Olimpio, Durães-Carvalho Ricardo, Diaz Ricardo Sobhie, Komninakis Shirley Vasconcelos
Abstract excerpt
We analyzed major and minority HIV-1 drug resistance mutations in treatment-experienced individuals with virological failure using next-generation sequencing. Conventional population-based sequencing has limited sensitivity for variants present at low intra-host frequencies, which may obscure resistant subpopulations in heavily treated patients. A total of 188 plasma samples collected between 2013 and 2015 were...
Topics
- Humans
- HIV-1
- High-Throughput Nucleotide Sequencing
- Drug Resistance, Viral
- HIV Infections
- Treatment Failure
- Mutation
- Anti-HIV Agents
- HIV Protease
- Female
- HIV Reverse Transcriptase
- Viral Load