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Article

Progressive emergence of an S153F plus R263K combination of integrase mutations in the proviral DNA of one individual successfully treated with dolutegravir.

The Journal of antimicrobial chemotherapy - 11 Feb 2021

Pham Hanh T, Alves Brunna M, Yoo Sunbin, Xiao Meng A, Leng Jing, Quashie Peter K, Soares Esmeralda A, Routy Jean-Pierre, Soares Marcelo A, Mesplède Thibault

Abstract excerpt

OBJECTIVES: The development of HIV drug resistance against the integrase strand transfer inhibitor dolutegravir is rare. We report here the transient detection, by near full-genome ultradeep sequencing, of minority HIV-1 subtype B variants bearing the S153F and R263K integrase substitutions in the proviral DNA from blood cells of one patient who successfully initiated dolutegravir-based ART, over 24 weeks. Our...

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Identifiers

PMID: 33184634
DOI: 10.1093/jac/dkaa471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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