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Article

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

5 Jan 2018

Abstract excerpt

BACKGROUND: Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, representing three distinct resistance pathways. The mechanisms that drive selection of a specific pathway are still poorly understood. We investigated the impact of the HIV-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29304821
DOI: 10.1186/s12977-017-0384-z

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