Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.

doi:10.1371/journal.pone.0090485

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Article

Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.

PloS one - 1 Jan 2014

Li Jonathan Z, Chapman Brad, Charlebois Patrick, Hofmann Oliver, Weiner Brian, Porter Alyssa J, Samuel Reshmi, Vardhanabhuti Saran, Zheng Lu, Eron Joseph, Taiwo Babafemi, Zody Michael C, Henn Matthew R, Kuritzkes Daniel R, Hide Winston, Wilson Cara C, Berzins Baiba I, Acosta Edward P, Bastow Barbara, Kim Peter S, Read Sarah W, Janik Jennifer, Meres Debra S, Lederman Michael M, Mong-Kryspin Lori, Shaw Karl E, Zimmerman Louis G, Leavitt Randi, De La Rosa Guy, Jennings Amy

Abstract excerpt

BACKGROUND: The impact of raltegravir-resistant HIV-1 minority variants (MVs) on raltegravir treatment failure is unknown. Illumina sequencing offers greater throughput than 454, but sequence analysis tools for viral sequencing are needed. We evaluated Illumina and 454 for the detection of HIV-1 raltegravir-resistant MVs. METHODS: A5262 was a single-arm study of raltegravir and darunavir/ritonavir in...

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PMID: 24603872
DOI: 10.1371/journal.pone.0090485
PMCID: PMC3946168

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