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Article

Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir.

The Journal of antimicrobial chemotherapy - 1 Mar 2010

Canducci Filippo, Marinozzi Maria Chiara, Sampaolo Michela, Boeri Enzo, Spagnuolo Vincenzo, Gianotti Nicola, Castagna Antonella, Paolucci Stefania, Baldanti Fausto, Lazzarin Adriano, Clementi Massimo

Abstract excerpt

OBJECTIVES: To understand the dynamic viral evolution observed during failure on raltegravir-containing regimens, we studied the genotypic and phenotypic patterns of resistance to raltegravir and the residual replication capacity (rRC) of HIV-1 variants selected in vivo. METHODS: Clonal genotypic analyses were performed on sequential HIV-1 integrase sequences amplified from 11 failing patients and sampled every...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20056687
DOI: 10.1093/jac/dkp477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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