Article
Deep sequencing of HIV-1 reveals extensive subtype variation and drug resistance after failure of first-line antiretroviral regimens in Nigeria.
The Journal of antimicrobial chemotherapy - 2 Feb 2022
El Bouzidi Kate, Datir Rawlings P, Kwaghe Vivian, Roy Sunando, Frampton Dan, Breuer Judith, Ogbanufe Obinna, Murtala-Ibrahim Fati, Charurat Man, Dakum Patrick, Sabin Caroline A, Ndembi Nicaise, Gupta Ravindra K
Abstract excerpt
BACKGROUND: Deep sequencing could improve understanding of HIV treatment failure and viral population dynamics. However, this tool is often inaccessible in low- and middle-income countries. OBJECTIVES: To determine the genetic patterns of resistance emerging in West African HIV-1 subtypes during first-line virological failure, and the implications for future antiretroviral options. PATIENTS AND METHODS:...
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