Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: a refined analysis by ultra-deep 454 pyrosequencing.

doi:10.1093/infdis/jir821

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Article

Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: a refined analysis by ultra-deep 454 pyrosequencing.

The Journal of infectious diseases - 15 Feb 2012

Armenia Daniele, Vandenbroucke Ina, Fabeni Lavinia, Van Marck Herwig, Cento Valeria, D'Arrigo Roberta, Van Wesenbeeck Liesbeth, Scopelliti Fernanda, Micheli Valeria, Bruzzone Bianca, Lo Caputo Sergio, Aerssens Jeroen, Rizzardini Giuliano, Tozzi Valerio, Narciso Pasquale, Antinori Andrea, Stuyver Lieven, Perno Carlo Federico, Ceccherini-Silberstein Francesca

Abstract excerpt

BACKGROUND: The dynamics of raltegravir-resistant variants and their impact on virologic response in 23 HIV-1-infected patients, who started a salvage raltegravir-containing regimen, were investigated. METHODS: Integrase population sequencing and Ultra-Deep-454 Pyrosequencing (UDPS) were performed on plasma samples at baseline and at raltegravir failure. All integrase mutations detected at a frequency ≥1% were...

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Identifiers

PMID: 22238474
DOI: 10.1093/infdis/jir821
PMCID: PMC3266134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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