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Article

Unravelling the dynamics of selection of multiresistant variants to integrase inhibitors in an HIV-1-infected child using ultra-deep sequencing.

The Journal of antimicrobial chemotherapy - 1 Mar 2017

Stefic Karl, Salmona Maud, Capitao Marisa, Splittgerber Marion, Maakaroun-Vermesse Zoha, Néré Marie-Laure, Bernard Louis, Chaix Marie-Laure, Barin Francis, Delaugerre Constance

Abstract excerpt

Background: Ultra-deep sequencing (UDS) allows detection of minority resistant variants (MRVs) with a threshold of 1% and could be useful to identify variants harbouring single or multiple drug-resistance mutations (DRMs). Objectives: We analysed the integrase gene region longitudinally using UDS in an HIV-1-infected child rapidly failing a raltegravir-based regimen. Methods: Longitudinal plasma samples at...

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Identifiers

PMID: 27999055
DOI: 10.1093/jac/dkw507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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