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Article

CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme.

Pharmacogenetics and genomics - 1 Nov 2010

Browning Sarah L, Tarekegn Ayele, Bekele Endashaw, Bradman Neil, Thomas Mark G

Abstract excerpt

BACKGROUND AND OBJECTIVES: CYP1A2 metabolizes various drugs, endogenous compounds and procarcinogens. As human genetic diversity has been reported to decrease with distance from Ethiopia, we resequenced CYP1A2 in five Ethiopian ethnic groups representing a rough northeast to southwest transect across Ethiopia to establish: (i) what variation exists in comparison with what is already known globally and (ii) what...

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PMID: 20881513
DOI: 10.1097/FPC.0b013e32833e90eb

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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