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Article

DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.

American journal of human genetics - 1 Sept 2002

Wooding S P, Watkins W S, Bamshad M J, Dunn D M, Weiss R B, Jorde L B

Abstract excerpt

CYP1A2 is a cytochrome P450 gene that is involved in human physiological responses to a variety of drugs and toxins. To investigate the role of population history and natural selection in shaping genetic diversity in CYP1A2, we sequenced a 3.7-kb region 5' from CYP1A2 in a diverse collection of 113 individuals from three major continental regions of the Old World (Africa, Asia, and Europe). We also examined...

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Identifiers

PMID: 12181774
DOI: 10.1086/342260
PMCID: PMC379190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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