Article
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.
Pharmacogenetics and genomics - 1 May 2006
Jiang Zhengwen, Dragin Nadine, Jorge-Nebert Lucia F, Martin Martha V, Guengerich F Peter, Aklillu Eleni, Ingelman-Sundberg Magnus, Hammons George J, Lyn-Cook Beverly D, Kadlubar Fred F, Saldana Shannon N, Sorter Michael, Vinks Alexander A, Nassr Nassr, von Richter Oliver, Jin Li, Nebert Daniel W
Abstract excerpt
The genotype responsible for more than 60-fold interindividual differences in human hepatic CYP1A2 constitutive expression is not understood. Resequencing the human CYP1A1_CYP1A2 locus (39.6 kb) in five major geographically isolated subgroups recently led to the identification of 85 single nucleotide polymorphisms (SNPs), 57 of which were double-hit SNPs. Here, we attempted to correlate the CYP1A2 genotype with a...
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