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Joint Analysis of Phenotypic and Genomic Diversity Sheds Light on the Evolution of Xenobiotic Metabolism in Humans.

Genome biology and evolution - 8 Dec 2022

Mouterde Médéric, Daali Youssef, Rollason Victoria, Čížková Martina, Mulugeta Anwar, Al Balushi Khalid A, Fakis Giannoulis, Constantinidis Theodoros C, Al-Thihli Khalid, Černá Marie, Makonnen Eyasu, Boukouvala Sotiria, Al-Yahyaee Said, Yimer Getnet, Černý Viktor, Desmeules Jules, Poloni Estella S

Abstract excerpt

Variation in genes involved in the absorption, distribution, metabolism, and excretion of drugs (ADME) can influence individual response to a therapeutic treatment. The study of ADME genetic diversity in human populations has led to evolutionary hypotheses of adaptation to distinct chemical environments. Population differentiation in measured drug metabolism phenotypes is, however, scarcely documented, often...

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PMID: 36445690
DOI: 10.1093/gbe/evac167
PMCID: PMC9750130

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