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Article

Contrasting exome constancy and regulatory region variation in the gene encoding CYP3A4: an examination of the extent and potential implications.

Pharmacogenetics and genomics - 1 Jun 2016

Creemer Olivia J, Ansari-Pour Naser, Ekong Rosemary, Tarekegn Ayele, Plaster Christopher, Bains Ripudaman K, Itan Yuval, Bekele Endashaw, Bradman Neil

Abstract excerpt

OBJECTIVE: CYP3A4 expression varies up to 100-fold among individuals, and, to date, genetic causes remain elusive. As a major drug-metabolizing enzyme, elucidation of such genetic causes would increase the potential for introducing personalized dose adjustment of therapies involving CYP3A4 drug substrates. The foetal CYP3A isoform, CYP3A7, is reported to be expressed in ∼10% of European adults and may thus...

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PMID: 27139836
DOI: 10.1097/FPC.0000000000000207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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