Article
Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.
Molecular pharmacology - 1 Sept 2003
Aklillu Eleni, Carrillo Juan Antonio, Makonnen Eyasu, Hellman Karin, Pitarque Marià, Bertilsson Leif, Ingelman-Sundberg Magnus
Abstract excerpt
CYP1A2 polymorphism has been well studied in white persons and Asians but not in Africans. We performed CYP1A2 genotype and phenotype analysis using caffeine in Ethiopians living in Ethiopia (n = 100) or in Sweden (n = 73). We sequenced the CYP1A2 gene using genomic DNA from 12 subjects, which revealed a novel intron 1 single-nucleotide polymorphism (SNP), -730C>T. We developed SNP-specific polymerase chain...
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