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Article

Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences.

Human genomics - 22 Apr 2024

Camara Mahamadou D, Zhou Yitian, De Sousa Taís Nóbrega, Gil José P, Djimde Abdoulaye A, Lauschke Volker M

Abstract excerpt

BACKGROUND: CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory drugs. Genetic variability is an important factor that influences CYP2C8 activity and modulates the pharmacokinetics, efficacy and safety of its substrates. RESULTS: We profiled the genetic landscape of CYP2C8 variability using data from 96 original studies and data...

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Identifiers

PMID: 38650020
DOI: 10.1186/s40246-024-00610-y
PMCID: PMC11034136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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