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Article

Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.

Journal of virology - 1 Dec 2010

Ito Kiyoaki, Qin Yanli, Guarnieri Michael, Garcia Tamako, Kwei Karen, Mizokami Masashi, Zhang Jiming, Li Jisu, Wands Jack R, Tong Shuping

Abstract excerpt

Mutations in the S region of the hepatitis B virus (HBV) envelope gene are associated with immune escape, occult infection, and resistance to therapy. We previously identified naturally occurring mutations in the S gene that alter HBV virion secretion. Here we used transcomplementation assay to confirm that the I110M, G119E, and R169P mutations in the S domain of viral envelope proteins impair virion secretion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20881037
DOI: 10.1128/JVI.01499-10
PMCID: PMC3004315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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