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Article

Dual defects in HBsAg antigenicity and secretion caused by the C138R mutation in the S gene trigger occult hepatitis B virus infection.

Journal of translational medicine - 5 Dec 2025

Hong Xiaodan, Chen Xinlei, Zhang Pengyue, Gao Zhengqi, Tao Chunhui, Wang Hua, Zhang Zhenhua

Abstract excerpt

BACKGROUND: Occult hepatitis B virus infection (OBI) carries high risk of transmissibility and pathogenicity. Mutations in the S gene are considered major contributors to OBI development. Our previous study identified the C138R mutation in the S gene of OBI patients. This study aimed to investigate the impact of the C138R mutation on HBsAg function and its mechanisms leading to OBI. METHODS: Full-length hepatitis...

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Hep G2 Cells
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Mice

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Protein Multimerization

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PMID: 41350719
DOI: 10.1186/s12967-025-07440-z
PMCID: PMC12679743

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