Article
A unique amino acid substitution, L215Q, in the hepatitis B virus small envelope protein of a genotype F isolate that inhibits secretion of hepatitis B virus subviral particles.
Intervirology - 1 Jan 2008
Araujo Natalia M, Vianna Carlos O A, Soares Caroline C, Gomes Selma A
Abstract excerpt
The small (S) envelope protein is the major component of hepatitis B virus surface antigen (HBsAg). Some mutations in the S-HBsAg coding region may cause deficiency in the secretion of both viral and empty subviral particles (SVPs) and lead to accumulation of HBsAg inside the cells. In this study, we identified a unique amino acid substitution (L215Q) in the carboxyl-terminal end of S-HBsAg of an HBV genotype F...
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