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Article

Impaired virion secretion by hepatitis B virus immune escape mutants and its rescue by wild-type envelope proteins or a second-site mutation.

Journal of virology - 1 Feb 2013

Kwei Karen, Tang Xiaoli, Lok Anna S, Sureau Camille, Garcia Tamako, Li Jisu, Wands Jack, Tong Shuping

Abstract excerpt

Hepatitis B virus immune escape mutants have been associated with vaccine failure and reinfection of grafted liver despite immune prophylaxis, but their biological properties remain largely unknown. Transfection of 20 such mutants in a human hepatoma cell line identified many with severe impairment in virion secretion, which can be rescued to various extents by coexpression of wild-type envelope proteins or...

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Identifiers

PMID: 23221548
DOI: 10.1128/JVI.02701-12
PMCID: PMC3571463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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