Article
Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2.
Viruses - 1 Sept 2020
Wang Qianru, Fu Shuwen, Zhang Jing, Yuan Quan, Li Jisu, Xia Ningshao, Wen Yu-Mei, Wang Yongxiang, Tong Shuping
Abstract excerpt
Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular/intracellular ratio of HBsAg suggesting more efficient secretion. The current study aimed to characterize the...
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