Article
Amino acid substitutions Q129N and T131N/M133T in hepatitis B surface antigen (HBsAg) interfere with the immunogenicity of the corresponding HBsAg or viral replication ability.
Virus research - 15 Sept 2018
Kang Yaoyue, Li Fahong, Guo Hongying, Yang Sisi, Zhang Yongmei, Zhu Haoxiang, Wang Jinyu, Mao Richeng, Qin Yanli, Xu Jie, Chen Xinwen, Wu Chunchen, Zhang Jiming
Abstract excerpt
Variants of hepatitis B surface antigen (HBsAg) influenced its antigenicity and immunogenicity. In our study, we aim to investigate biological significance of amino acid (aa) substitutions in HBsAg, Q129 N and T131 N/M133 T, for glycosylation, antigenicity and immunogenicity of variant HBsAg (vtHBsAg) and viral replication. Expression plasmids of vtHBsAg with aa substitutions Q129 L, T123 N, Q129 N and...
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