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Article

Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency.

Diabetes - 1 Jan 2011

Cui Ju, Wang Zai, Cheng Qianni, Lin Raozhou, Zhang Xin-Mei, Leung Po Sing, Copeland Neal G, Jenkins Nancy A, Yao Kwok-Ming, Huang Jian-Dong

Abstract excerpt

OBJECTIVE: Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological r...

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Source

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Identifiers

PMID: 20870970
DOI: 10.2337/db09-1078
PMCID: PMC3012189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20870970-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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