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Article

Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.

Cellular and molecular life sciences : CMLS - 1 Apr 2012

Cape Austin, Chen Xingxing, Wang Chuan-En, O'Neill Ashley, Lin Yung-Feng, He Jun, Xu Xing-Shun, Yi Hong, Li He, Li Shihua, Li Xiao-Jiang

Abstract excerpt

Hap1 was originally identified as a neuronal protein that interacts with huntingtin, the Huntington's disease (HD) protein. Later studies revealed that Hap1 participates in intracellular trafficking in neuronal cells and that this trafficking function can be adversely affected by mutant huntingtin. Hap1 is also present in pancreatic β-cells and other endocrine cells; however, the role of Hap1 in these endocrine...

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Identifiers

PMID: 21544547
DOI: 10.1007/s00018-011-0692-8
PMCID: PMC3193590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.PMID 21544547Read ↗

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