Article
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
Cellular and molecular life sciences : CMLS - 1 Apr 2012
Cape Austin, Chen Xingxing, Wang Chuan-En, O'Neill Ashley, Lin Yung-Feng, He Jun, Xu Xing-Shun, Yi Hong, Li He, Li Shihua, Li Xiao-Jiang
Abstract excerpt
Hap1 was originally identified as a neuronal protein that interacts with huntingtin, the Huntington's disease (HD) protein. Later studies revealed that Hap1 participates in intracellular trafficking in neuronal cells and that this trafficking function can be adversely affected by mutant huntingtin. Hap1 is also present in pancreatic β-cells and other endocrine cells; however, the role of Hap1 in these endocrine...
Topics
- Animals
- Cell Line
- Glucose
- Huntington Disease
- Insulin
- Insulin-Secreting Cells
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Nerve Tissue Proteins