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Article

Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis.

PloS one - 9 Dec 2010

Ohara-Imaizumi Mica, Yoshida Masashi, Aoyagi Kyota, Saito Taro, Okamura Tadashi, Takenaka Hitoshi, Akimoto Yoshihiro, Nakamichi Yoko, Takanashi-Yanobu Rieko, Nishiwaki Chiyono, Kawakami Hayato, Kato Norihiro, Hisanaga Shin-ichi, Kakei Masafumi, Nagamatsu Shinya

Abstract excerpt

BACKGROUND: A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in β cells is largely unknown. Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insulin release prof...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21151568
DOI: 10.1371/journal.pone.0015553
PMCID: PMC3000340

Genes

CDKAL1
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151568-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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