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Article

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

The Journal of clinical investigation - 1 Oct 2002

Xuan Shouhong, Kitamura Tadahiro, Nakae Jun, Politi Katerina, Kido Yoshiaki, Fisher Peter E, Morroni Manrico, Cinti Saverio, White Morris F, Herrera Pedro L, Accili Domenico, Efstratiadis Argiris

Abstract excerpt

Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by...

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Identifiers

PMID: 12370279
DOI: 10.1172/JCI15276
PMCID: PMC151144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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