Article

PFKFB3 Depletion Activates β-Cell Replication by Cell Competitive Culling of Compromised β-Cells Under Stress

2021-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Highly conserved hypoxia-inducible factor 1 alpha (HIF1α) and its target 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) play a critical role in the survival of damaged β-cells in type 2 diabetes (T2D) while rendering β-cells non-responsive to glucose stimulation by mitochondrial suppression. HIF1α-PFKFB3 is activated in 30-50% of all β-cells in diabetic islets, leaving an open qu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 908a2497-c6b2-58a9-88b9-944326572ed6
DOI: 10.1101/2021.04.07.438857

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PFKFB3 Depletion Activates β-Cell Replication by Cell Competitive Culling of Compromised β-Cells Under StressDOI 10.1101/2021.04.07.438857Read

Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasisSemantic proximity Read

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Semantic proximity Read

FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stressSemantic proximity Read

Genetic and biochemical pathways of β‐cell failure in type 2 diabetesSemantic proximity Read

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.Semantic proximity Read

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function.Semantic proximity Read

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and functionSemantic proximity Read

Role for Activating Transcription Factor 3 in Stress-Induced β-Cell ApoptosisSemantic proximity Read

MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretionSemantic proximity Read

Glucose metabolism: key endogenous regulator of β‐cell replication and survivalSemantic proximity Read

Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionSemantic proximity Read

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.Semantic proximity Read