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Article

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

Biochimica et biophysica acta - 1 Sept 2007

Lee Ji-Yeon, Gavrilova Oksana, Davani Behrous, Na Risu, Robinson Gertraud W, Hennighausen Lothar

Abstract excerpt

In insulinoma cell lines proliferation and insulin gene transcription are stimulated by growth hormone and prolactin, which convey their signals through the transcription factors Stat5a and 5b (referred to as Stat5). However, the contribution of Stat5 to the physiology of beta-cells in vivo could...

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Identifiers

PMID: 17599554
DOI: 10.1016/j.bbamcr.2007.05.010
PMCID: PMC2695665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17599554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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