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Article

Ins1 Cre knock-in mice for beta cell-specific gene recombination

10 Dec 2014

Abstract excerpt

AIMS/HYPOTHESIS: Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of major forms of diabetes. Selective gene inactivation in pancreatic beta cells, using the Cre-lox...

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PMID: 25500700
DOI: 10.1007/s00125-014-3468-5

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