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Article

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Diabetologia - 1 Jun 2007

Cantley J, Choudhury A I, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud S J, Withers D J

Abstract excerpt

AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gene targeting using the Cre/loxP system has demonstrated that mice lacking insulin receptor substrate 2 (IRS2) in the beta cell have reduced beta cell mass. However, these studies have been complicat...

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Source

Identifiers

PMID: 17393136
DOI: 10.1007/s00125-007-0637-9

Genes

IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17393136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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