Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2009

Zolk Oliver, Solbach Thomas F, König Jörg, Fromm Martin F

Abstract excerpt

The organic cation transporter 2 (OCT2, SLC22A2) plays an important role for renal drug elimination. Recent clinical studies indicate an impact of the frequent nonsynonymous c.808G>T (p.270Ala>Ser) polymorphism on renal clearance of metformin and the extent of the metformin-cimetidine interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Metabolic Clearance Rate
Share to Metformin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organic Cation Transport Proteins

Share to Organic Cation Transporter 1

Share to Protein Isoforms

Share to Serine

Share to Subcellular Fractions

Source

Identifiers

PMID: 19251820
DOI: 10.1124/dmd.108.023762

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19251820-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.PMID 19251820Read ↗

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.Semantic proximity Read ↗

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.Semantic proximity Read ↗

Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.Semantic proximity Read ↗

Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions.Semantic proximity Read ↗

Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.Semantic proximity Read ↗

Polymorphism in human organic cation transporters and metformin action.Semantic proximity Read ↗

Genetic variants of the organic cation transporter 2 influence the disposition of metformin.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).Semantic proximity Read ↗

Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin.Semantic proximity Read ↗

Current understanding of the pharmacogenomics of metformin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.