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Article

Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms.

Journal of pharmacological sciences - 1 Jan 2010

Sakata Takeshi, Anzai Naohiko, Kimura Toru, Miura Daisaku, Fukutomi Toshiyuki, Takeda Michio, Sakurai Hiroyuki, Endou Hitoshi

Abstract excerpt

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [(3)H]histamine and [(3)H]MPP(+), although their protein expressions were detected in the plasma membrane of transfected cells. This study...

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PMID: 20562519
DOI: 10.1254/jphs.09331sc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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