Article
The linker domain of basal transcription factor TFIIB controls distinct recruitment and transcription stimulation functions.
Nucleic acids research - 1 Jan 2011
Wiesler Simone C, Weinzierl Robert O J
Abstract excerpt
RNA polymerases (RNAPs) require basal transcription factors to assist them during transcription initiation. One of these factors, TFIIB, combines promoter recognition, recruitment of RNAP, promoter melting, start site selection and various post-initiation functions. The ability of 381 site-directed mutants in the TFIIB 'linker domain' to stimulate abortive transcription was systematically quantitated using...
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