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Article

Effects of DNA strand breaks on transcription by RNA polymerase III: insights into the role of TFIIIB and the polarity of promoter opening.

The EMBO journal - 15 Oct 2002

Kassavetis George A, Grove Anne, Geiduschek E Peter

Abstract excerpt

Certain deletion mutants of the Brf1 and Bdp1 subunits of transcription factor (TF) IIIB retain the ability to recruit RNA polymerase (pol) III to its promoters, but fail to support promoter opening: deletions within an internal Bdp1 segment interfere with initiation of DNA strand separation, and an N-terminal Brf1 deletion blocks propagation of promoter opening past the transcriptional start site. The ability of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12374751
DOI: 10.1093/emboj/cdf533
PMCID: PMC129065

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Source receipt: pubmed, retrieved 7 Sept 2026.

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