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Article

A functional role for the switch 2 region of yeast RNA polymerase II in transcription start site utilization and abortive initiation.

The Journal of biological chemistry - 14 Oct 2005

Majovski Robert C, Khaperskyy Denys A, Ghazy Mohamed A, Ponticelli Alfred S

Abstract excerpt

RNA polymerase II (RNAPII) is responsible for the synthesis of mRNA from eukaryotic protein-encoding genes. In this study, site-directed mutagenesis was employed to probe the function of residues within the Saccharomyces cerevisiae RNAPII active center in the mechanism of transcription start site utilization. We report here the identification of two mutations in the switch 2 region, rpb1-K332A and rpb1-R344A,...

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PMID: 16081422
DOI: 10.1074/jbc.M502932200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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