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Article

Revealing the functions of TFIIB.

Transcription - 1 Jan 2000

Weinzierl Robert O J, Wiesler Simone C

Abstract excerpt

The TFIIB linker domain stimulates the catalytic activity of archaeal RNAP. By characterising a range of super-stimulating mutants we identified a novel rate-limiting step in transcription initiation. Our results help to interpret structural findings and pave the way towards higher-resolution structures of the RNAP-TFIIB linker interface.

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Share to Archaeal Proteins
Share to Crystallography, X-Ray
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Protein Structure, Tertiary

Share to Sequence Homology, Amino Acid

Share to Transcription Factor TFIIB

Share to Transcription, Genetic

Source

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Identifiers

PMID: 22223047
DOI: 10.4161/trns.2.6.18076
PMCID: PMC3265785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Revealing the functions of TFIIB.PMID 22223047Read ↗

The linker domain of basal transcription factor TFIIB controls distinct recruitment and transcription stimulation functions.Semantic proximity Read ↗

A ubiquitous disordered protein interaction module orchestrates transcription elongation.Semantic proximity Read ↗

Interaction of the TFIIB zinc ribbon with RNA polymerase II.Semantic proximity Read ↗

Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.Semantic proximity Read ↗

Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit.Semantic proximity Read ↗

Structure-function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation.Semantic proximity Read ↗

TFIIA interacts with TFIID via association with TATA-binding protein and TAF40.Semantic proximity Read ↗

Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.Semantic proximity Read ↗

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.Semantic proximity Read ↗

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