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Article

Functional interactions between the LRP6 WNT co-receptor and folate supplementation.

Human molecular genetics - 1 Dec 2010

Gray Jason D, Nakouzi Ghunwa, Slowinska-Castaldo Bozena, Dazard Jean-Eudes, Rao J Sunil, Nadeau Joseph H, Ross M Elizabeth

Abstract excerpt

Crooked tail (Cd) mice bear a gain-of-function mutation in Lrp6, a co-receptor for canonical WNT signaling, and are a model of neural tube defects (NTDs), preventable with dietary folic acid (FA) supplementation. Whether the FA response reflects a direct influence of FA on LRP6 function was tested with prenatal supplementation in LRP6-deficient embryos. The enriched FA (10 ppm) diet reduced the occurrence of...

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Source

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Identifiers

PMID: 20843827
DOI: 10.1093/hmg/ddq384
PMCID: PMC2972692

Genes

LRP6
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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