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Article

LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.

Human molecular genetics - 1 Nov 2013

Gray Jason D, Kholmanskikh Stanislav, Castaldo Bozena S, Hansler Alex, Chung Heekyung, Klotz Brian, Singh Shawn, Brown Anthony M C, Ross M Elizabeth

Abstract excerpt

Low-density lipoprotein receptor related protein 6 (Lrp6) mutational effects on neurulation were examined using gain (Crooked tail, Lrp6(Cd)) and loss (Lrp6(-)) of function mouse lines. Two features often associated with canonical Wnt signaling, dorsal-ventral patterning and proliferation, were no different from wild-type (WT) in the Lrp6(Cd/Cd) neural tube. Lrp6(-/-) embryos showed reduced proliferation and...

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Source

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Identifiers

PMID: 23773994
DOI: 10.1093/hmg/ddt277
PMCID: PMC3792688

Genes

DAAM1
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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