Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1

Abstract excerpt

<h4>ABSTRACT</h4> Folic acid (FA) supplementation during pregnancy is the commonly accepted treatment to prevent neurodevelopmental defects. The mechanism by which FA prevents neural tube defects (NTDs) remains unclear. FA also prevents other developmental malformations, including the alcohol-induced malformations in Fetal Alcohol Syndrome models. We show that FA acts through a metabolic link to retinoic acid (RA...

Topics

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• Disease Models, Animal
• Folate and B Vitamins Research
• Genetic Predisposition to Disease
• Genomics
• Mutation
• Neural Tube Defects
• Prenatal Substance Exposure Effects
• Retinoids in leukemia and cellular processes

Identifiers and source

Literature Corpus work

48c1c679-483a-55a6-9aea-2f50ce5b46f8

DOI

10.1101/2025.10.14.681787