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Article

Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.

Human molecular genetics - 15 Sept 2011

Marean Amber, Graf Amanda, Zhang Ying, Niswander Lee

Abstract excerpt

Neural tube defects (NTDs), a common birth defect in humans, result from the failure of the embryonic neural tube (NT) to close properly. NT closure is a complex, poorly understood morphogenetic process influenced by genes and environment. The most effective environmental influence in decreasing the risk for NTDs is folic acid (FA) fortification and supplementation, and these findings led to the recommendation of...

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Identifiers

PMID: 21693562
DOI: 10.1093/hmg/ddr289
PMCID: PMC3159553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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